I think my enjoyment of Marv Wolfman & Gene Colan's Tomb of Dracula comes from my interest in Bram Stoker's original novel. I know that in modern readings people tend to prefer Dracula to the actual protagonists, but when I read it (I think I was 12?) I liked the good guys; John Seward, Jonathan & Mina Harker, Quincey Morris and Abraham Van Helsing were the point of view characters in the novel and their trials while facing the menace of Dracula was what engaged me as a reader.
Similarly, Wolfman often ran Tomb of Dracula from the perspective of the people hunting him; Frank Drake, Quincy Harker, Rachel Van Helsing, Harold H. Harold, Taj Nital and, of course, Blade. I enjoyed all of these characters but the stories which really stood out were the offbeat tales; Dracula writing an entry in his diary (#15), or a hardboiled detective story where the narrating private eye runs into Dracula (#25); those were gold.
Dracula himself was always a strong figure, usually being followed in hot pursuit by the vampire hunters, but occasionally pit against someone more evil than he was (like Dr. Sun or Satan himself). I really appreciated that Tomb of Dracula didn't over-romanticize Dracula (a problem a lot of contemporary vampire fiction has), notably in issue #50 where he meets a woman who thinks of him as a romantic hero...it ends badly for her (Buffy fans may be reminded of "Lie to Me"). And unlike most comics, Christianity plays a part when God himself takes a dim view of Dracula and when Dracula has a son, a battle plays out for his soul. It's rare to see God utilized in a comic book (for something other than mockery).
Marv Wolfman didn't arrive until issue #7 of Tomb of Dracula but he made it his own; Gene Colan was there from start to finish and he's probably more strongly associated with Tomb of Dracula than anything else in his 60+ year career.